Article
Genetic variation in LIN28B is associated with the timing of puberty.
Nature genetics - 1 Jun 2009
Ong Ken K, Elks Cathy E, Li Shengxu, Zhao Jing Hua, Luan Jian'an, Andersen Lars B, Bingham Sheila A, Brage Soren, Smith George Davey, Ekelund Ulf, Gillson Christopher J, Glaser Beate, Golding Jean, Hardy Rebecca, Khaw Kay-Tee, Kuh Diana, Luben Robert, Marcus Michele, McGeehin Michael A, Ness Andrew R, Northstone Kate, Ring Susan M, Rubin Carol, Sims Matthew A, Song Kijoung, Strachan David P, Vollenweider Peter, Waeber Gerard, Waterworth Dawn M, Wong Andrew, Deloukas Panagiotis, Barroso Inês, Mooser Vincent, Loos Ruth J, Wareham Nicholas J
Abstract excerpt
The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 × 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 × 10(-10); combined P =...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.