LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty

Abstract excerpt

BACKGROUND: Pubertal timing is a strongly heritable trait, but no single puberty gene has been identified. Thus, the genetic background of idiopathic central precocious puberty (ICPP) is poorly understood. Overall, the genetic modulation of pubertal onset most likely arises from the additive effect of multiple genes, but also monogenic causes of ICPP probably exist, as cases of familial ICPP have been reported....

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