Article

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

2023-06-20

Abstract excerpt

Pubertal timing varies considerably and has been associated with a range of health outcomes in later life. To elucidate the underlying biological mechanisms, we performed multi-ancestry genetic analyses in ∼800,000 women, identifying 1,080 independent signals associated with age at menarche. Collectively these loci explained 11% of the trait variance in an independent sample, with women at the top and bottom 1% of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88ae22e2-a16e-5119-b435-f0d0f32d1969
DOI: 10.1101/2023.06.14.23291322

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Understanding the genetic complexity of puberty timing across the allele frequency spectrumDOI 10.1101/2023.06.14.23291322Read

Understanding the genetic complexity of puberty timing across the allele frequency spectrum.Semantic proximity Read

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.Semantic proximity Read

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibilitySemantic proximity Read

Lack of a genetic risk continuum between pubertal timing in the general population and idiopathic hypogonadotropic hypogonadism.Semantic proximity Read

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.Semantic proximity Read

Variation in the Timing of Puberty: Clinical Spectrum and Genetic InvestigationSemantic proximity Read

Genetic determinants of pubertal timing in the general population.Semantic proximity Read

Variation in the timing of puberty: clinical spectrum and genetic investigation.Semantic proximity Read

The Genetic Basis of Delayed Puberty.Semantic proximity Read

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.Semantic proximity Read

Genetic Regulation of Puberty Timing in HumansSemantic proximity Read

Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood.Semantic proximity Read