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Sex-specific regulation of weight and puberty by the Lin28/let-7 axis

23 Dec 2015

Abstract excerpt

Growth and pubertal timing differ in boys and girls. Variants in/near LIN28B associate with age at menarche (AAM) in genome-wide association studies and some AAM-related variants associate with growth in a sex-specific manner. Sex-specific growth patterns in response to Lin28b perturbation have been detected in mice, and overexpression of Lin28a has been shown to alter pubertal timing in female mice. To...

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PMID: 26698568
DOI: 10.1530/joe-15-0360

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