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Article

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.

Neurobiology of aging - 1 Mar 2020

Moore Annah M, Mahoney Emily, Dumitrescu Logan, De Jager Philip L, Koran Mary Ellen I, Petyuk Vladislav A, Robinson Renã As, Ruderfer Douglas M, Cox Nancy J, Schneider Julie A, Bennett David A, Jefferson Angela L, Hohman Timothy J

Abstract excerpt

Literature suggests vascular endothelial growth factor A (VEGFA) is protective among those at highest risk for Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers represent a highly susceptible population for cognitive decline, and VEGF may confer distinct protection among APOE-ε4 carriers. We evaluated interactions between cortical expression of 10 VEGF gene family members and APOE-ε4 genotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31791659
DOI: 10.1016/j.neurobiolaging.2019.10.021
PMCID: PMC7064375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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