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Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment

30 Jun 2016

Abstract excerpt

Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with increased neurodegeneration and vascular impairments. Vascular endothelial growth factor (VEGF), originally described as a key angiogenic factor, has recently been shown to play a crucial role in the nervous system. The objective of this research is to examine the role of VEGF in mediating the...

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PMID: 27372644
DOI: 10.3233/jad-160182

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