Article
Variants in the APOE gene are associated with improved outcome after anti-VEGF treatment for neovascular AMD.
Investigative ophthalmology & visual science - 8 Jun 2011
Wickremasinghe Sanjeewa S, Xie Jing, Lim Jonathan, Chauhan Devinder S, Robman Luba, Richardson Andrea J, Hageman Gregory, Baird Paul N, Guymer Robyn
Abstract excerpt
PURPOSE: Anti-vascular endothelial growth factor (anti-VEGF) drugs have dramatically improved the treatment of neovascular AMD. In pivotal studies, almost 90% of patients maintain vision, with approximately 30% showing significant improvement. Despite these successes, 10% to 15% of patients continue to lose vision, even with treatment. It has been reported that variants in some AMD-associated genes influence...
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