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Article

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

1 Feb 2008

Abstract excerpt

The Notch ligand Jagged1 (Jag1) is essential for vascular remodeling and has been linked to congenital heart disease in humans, but its precise role in various cell types of the cardiovascular system has not been extensively investigated. We show that endothelial-specific deletion of Jag1 results in embryonic lethality and cardiovascular defects, recapitulating the Jag1 null phenotype. These embryos show striking...

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PMID: 18245384
DOI: 10.1073/pnas.0709663105

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