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Article

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

Circulation research - 1 Apr 2011

del Monte Gonzalo, Casanova Jesús C, Guadix Juan Antonio, MacGrogan Donal, Burch John B E, Pérez-Pomares José María, de la Pompa José Luis

Abstract excerpt

RATIONALE: The proepicardium is a transient structure comprising epicardial progenitor cells located at the posterior limit of the embryonic cardiac inflow. A network of signals regulates proepicardial cell fate and defines myocardial and nonmyocardial domains at the venous pole of the heart. During cardiac development, epicardial-derived cells also contribute to coronary vessel morphogenesis. OBJECTIVE: To study...

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Source

Identifiers

PMID: 21311046
DOI: 10.1161/CIRCRESAHA.110.229062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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