Article
Transcription factor CHF1/Hey2 regulates coronary vascular maturation.
Mechanisms of development - 1 Jan 2000
Watanabe Tokumitsu, Koibuchi Nobutaka, Chin Michael T
Abstract excerpt
The transcription factor CHF1/Hey2 has been implicated in a variety of cardiovascular developmental abnormalities including ventricular septal defect, deformed valves and cardiomyopathy. To date, its role in coronary vascular development remains unknown. We have found that KO mice developed coronary vascular abnormalities accompanied by a thin compact ventricular myocardium but grossly normal epicardial and...
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