Article
Molecular mechanisms controlling the coupled development of myocardium and coronary vasculature.
Clinical science (London, England : 1979) - 1 Jul 2006
Bhattacharya Shoumo, Macdonald Simon T, Farthing Cassandra R
Abstract excerpt
Cardiac failure affects 1.5% of the adult population and is predominantly caused by myocardial dysfunction secondary to coronary vascular insufficiency. Current therapeutic strategies improve prognosis only modestly, as the primary cause -- loss of normally functioning cardiac myocytes -- is not being corrected. Adult cardiac myocytes are unable to divide and regenerate to any significant extent following injury....
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