Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation.

doi:10.1126/scitranslmed.aax0904

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Article

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation.

Science translational medicine - 27 Nov 2019

Austin James W, Buckner Clarisa M, Kardava Lela, Wang Wei, Zhang Xiaozhen, Melson Valerie A, Swanson Ryan G, Martins Andrew J, Zhou Julian Q, Hoehn Kenneth B, Fisk J Nicholas, Dimopoulos Yiannis, Chassiakos Alexander, O'Dell Sijy, Smelkinson Margery G, Seamon Catherine A, Kwan Richard W, Sneller Michael C, Pittaluga Stefania, Doria-Rose Nicole A, McDermott Adrian, Li Yuxing, Chun Tae-Wook, Kleinstein Steven H, Tsang John S, Petrovas Constantinos, Moir Susan

Abstract excerpt

Nearly all chronic human infections are associated with alterations in the memory B cell (MBC) compartment, including a large expansion of CD19hiT-bethi MBC in the peripheral blood of HIV-infected individuals with chronic viremia. Despite their prevalence, it is unclear how these B cells arise and whether they contribute to the inefficiency of antibody-mediated immunity in chronic infectious diseases. We...

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Identifiers

PMID: 31776286
DOI: 10.1126/scitranslmed.aax0904
PMCID: PMC7479651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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