Article
CD27-CD38+ B cells accumulated in early HIV infection exhibit transitional profile and promote HIV disease progression.
Cell reports - 13 Jul 2021
Fu Yajing, Zhang Zining, Yang Zhijun, Jiang Yongjun, Han Xiaoxu, Xu Junjie, Chu Zhenxing, Ding Haibo, He Sijia, Shang Hong
Abstract excerpt
Although peripheral B cell dysfunction in early HIV infection is established, how B cell subsets are altered by HIV infection is poorly understood. While investigating B cell subsets among individuals recently infected with HIV, we observe an accumulation of CD27-CD38+ B cells and find that these cells can directly facilitate HIV infection of primary CD4+ T cells in vitro. Comprehensive analyses of the phenotype,...
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