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Article

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals.

The Journal of experimental medicine - 4 Aug 2008

Moir Susan, Ho Jason, Malaspina Angela, Wang Wei, DiPoto Angela C, O'Shea Marie A, Roby Gregg, Kottilil Shyam, Arthos James, Proschan Michael A, Chun Tae-Wook, Fauci Anthony S

Abstract excerpt

Human immunodeficiency virus (HIV) disease leads to impaired B cell and antibody responses through mechanisms that remain poorly defined. A unique memory B cell subpopulation (CD20(hi)/CD27(lo)/CD21(lo)) in human tonsillar tissues was recently defined by the expression of the inhibitory receptor Fc-receptor-like-4 (FCRL4). In this study, we describe a similar B cell subpopulation in the blood of HIV-viremic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18625747
DOI: 10.1084/jem.20072683
PMCID: PMC2525604

Genes

FCRL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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