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Article

Screening Human Embryos for Polygenic Traits Has Limited Utility.

Cell - 27 Nov 2019

Karavani Ehud, Zuk Or, Zeevi Danny, Barzilai Nir, Stefanis Nikos C, Hatzimanolis Alex, Smyrnis Nikolaos, Avramopoulos Dimitrios, Kruglyak Leonid, Atzmon Gil, Lam Max, Lencz Todd, Carmi Shai

Abstract excerpt

The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which undermines discussion of associated ethical concerns. Here, we use theory, simulations, and real data...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31761530
DOI: 10.1016/j.cell.2019.10.033
PMCID: PMC6957074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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