Article
Problems with Using Polygenic Scores to Select Embryos.
The New England journal of medicine - 1 Jul 2021
Turley Patrick, Meyer Michelle N, Wang Nancy, Cesarini David, Hammonds Evelynn, Martin Alicia R, Neale Benjamin M, Rehm Heidi L, Wilkins-Haug Louise, Benjamin Daniel J, Hyman Steven, Laibson David, Visscher Peter M
Abstract excerpt
Companies have recently begun to sell a new service to patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These scores represent individualized predictions of health and other outcomes derived from genomewide association studies in adults to partially predict these outcomes. This article includes a discussion of many factors that lower the predictive power of polygenic...
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