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Article

Arf6-driven endocytic recycling of CD147 determines HCC malignant phenotypes.

Journal of experimental & clinical cancer research : CR - 21 Nov 2019

Qi Shanshan, Su Linjia, Li Jing, Zhang Chuanshan, Ma Zhe, Liu Guiqiu, Zhang Qing, Jia Guhe, Piao Yongjun, Zhang Sihe

Abstract excerpt

BACKGROUND: Adhesion molecules distributed on the cell-surface depends upon their dynamic trafficking that plays an important role during cancer progression. ADP-ribosylation factor 6 (Arf6) is a master regulator of membrane trafficking. CD147, a tumor-related adhesive protein, can promote the invasion of liver cancer. However, the role of Arf6 in CD147 trafficking and its contribution to liver cancer progression...

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Identifiers

PMID: 31752956
DOI: 10.1186/s13046-019-1464-9
PMCID: PMC6868876

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