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Regulation of Rho GTPases by RhoGDIs in Human Cancers

5 Sept 2019

Abstract excerpt

Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family. Dissociation of Rho GTPases from RhoGDIs is necessary for their spatiotemporal activation and is dynamically regulated by several mechanisms, such as phosphorylation, sumoylation, and protein interaction. The...

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PMID: 31492019
DOI: 10.3390/cells8091037

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