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Article

A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis.

Molecular biology of the cell - 1 Apr 2005

Tanabe Kenji, Torii Tetsuo, Natsume Waka, Braesch-Andersen Sten, Watanabe Toshio, Satake Masanobu

Abstract excerpt

ADP-ribosylation factor 6 (Arf6) is a small-GTPase that regulates the membrane trafficking between the plasma membrane and endosome. It is also involved in the reorganization of the actin cytoskeleton. GTPase-activating protein (GAP) is a critical regulator of Arf function as it inactivates Arf. Here, we identified a novel species of GAP denoted as SMAP1 that preferentially acts on Arf6. Although overexpression...

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Identifiers

PMID: 15659652
DOI: 10.1091/mbc.e04-08-0683
PMCID: PMC1073646

Genes

SMAP1
ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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