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Article

ARF6 promotes the nuclear translocation of β-catenin to facilitate AFP deficiency-mediated metastasis in CTNNB1S33Y-mutant hepatocellular carcinoma.

Cell biology and toxicology - 21 May 2026

Zhang Ruitian, Dong Longxuan, Yang Junyi, Guo Qinglong, Pan Di, Xun Chen, Wei Libin

Abstract excerpt

The mortality rate associated with hepatocellular carcinoma (HCC) remains alarmingly high, positioning it as a primary lethal cancer worldwide, primarily driven by its high degree of malignancy, recurrence, and metastasis. The high heterogeneity of HCC necessitates the urgent identification of new therapeutic targets and molecular pathways. Our previous research observed that alpha-fetoprotein (AFP) deficiency...

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Identifiers

PMID: 42165897
DOI: 10.1007/s10565-026-10211-1
PMCID: PMC13473338

Genes

ARF6
AFP
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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ARF6 promotes the nuclear translocation of β-catenin to facilitate AFP deficiency-mediated metastasis in CTNNB1S33Y-mutant hepatocellular carcinoma.PMID 42165897Read ↗

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