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Article

ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

26 Oct 2015

Abstract excerpt

Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is essential for cancer cell biology. In this study, we identify ARF6 together with c-Jun NH2-terminal kinase-interacting protein 3 and 4 (JIP3 and JIP4)...

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PMID: 26504170
DOI: 10.1083/jcb.201506002

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