Article

ARF6-dependent endocytic trafficking of the Interferon-γ receptor drives adaptive immune resistance in cancer

2023-10-02

Abstract excerpt

Adaptive immune resistance (AIR) is a protective process used by cancer to escape elimination by CD8 + T cells. Inhibition of immune checkpoints PD-1 and CTLA-4 specifically target Interferon-gamma (IFNγ)-driven AIR. AIR begins at the plasma membrane where tumor cell-intrinsic cytokine signaling is initiated. Thus, plasma membrane remodeling by endomembrane trafficking could regulate AIR. Herein we report that th...

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Literature Corpus work: 9416aaf2-4fc8-5153-a8dd-5b236beca70d
DOI: 10.1101/2023.09.29.560199

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