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Article

EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer

5 Jul 2023

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance, and metastasis in epithelial malignancies. However, the way in which EMT orchestrates disparate biological processes remains unclear. Here, we identify an EMT-activated vesicular trafficking network that coordinates promigratory focal adhesion dynamics with an immunosuppressive secretory program in lung adenocarcinoma (LUAD)....

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PMID: 37406091
DOI: 10.1073/pnas.2220276120

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