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GGA2 and RAB13 promote activity-dependent β1-integrin recycling

10 May 2019

Abstract excerpt

β1-integrins mediate cell-matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion. Here, we employ an RNAi screen to characterize regulators of integrin traffic and identify the association of Golgi-localized gamma ear-containing Arf-binding protein 2 (GGA2) with β1-integrin, and its role in recycling of...

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PMID: 31076515
DOI: 10.1242/jcs.233387

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