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Article

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing.

Acta neuropathologica communications - 20 Nov 2019

Lenting Krissie, van den Heuvel Corina N A M, van Ewijk Anne, ElMelik Duaa, de Boer Remco, Tindall Elizabeth, Wei Ge, Kusters Benno, Te Dorsthorst Maarten, Ter Laan Mark, Huynen Martijn A, Leenders William P

Abstract excerpt

Many biology-based precision drugs are available that neutralize aberrant molecular pathways in cancer. Molecular heterogeneity and the lack of reliable companion diagnostic biomarkers for many drugs makes targeted treatment of cancer inaccurate for many individuals. Identifying actionable hyperactive biological pathways in individual cancers may improve this situation.To achieve this we applied a novel targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31747973
DOI: 10.1186/s40478-019-0826-z
PMCID: PMC6865071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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