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Article

The Glioma-IRE project - Molecular profiling in patients with glioma: steps toward an individualized diagnostic and therapeutic approach.

Journal of translational medicine - 23 Mar 2023

Villani Veronica, Casini Beatrice, Tanzilli Antonio, Lecce Mario, Rasile Fabrizio, Telera Stefano, Pace Andrea, Piludu Francesca, Terrenato Irene, Rollo Francesca, De Nicola Francesca, Fanciulli Maurizio, Pallocca Matteo, Ciliberto Gennaro, Carosi Mariantonia

Abstract excerpt

BACKGROUND: This study aimed to characterize the genetic profile of patients with glioma and discuss the impact of next-generation sequencing in glioma diagnosis and treatment. METHODS: Between 2019 and 2022, we analyzed the genetic profile of 99 patients with glioma through the Oncomine Focus Assay. The assay enables the detection of mutations in 52 driver genes, including single nucleotide variants (SNVs), copy...

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Identifiers

PMID: 36959606
DOI: 10.1186/s12967-023-04057-y
PMCID: PMC10035236

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