Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.

doi:10.1007/s00401-015-1519-8

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Article

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.

Acta neuropathologica - 1 Jun 2016

Sahm Felix, Schrimpf Daniel, Jones David T W, Meyer Jochen, Kratz Annekathrin, Reuss David, Capper David, Koelsche Christian, Korshunov Andrey, Wiestler Benedikt, Buchhalter Ivo, Milde Till, Selt Florian, Sturm Dominik, Kool Marcel, Hummel Manuela, Bewerunge-Hudler Melanie, Mawrin Christian, Schüller Ulrich, Jungk Christine, Wick Antje, Witt Olaf, Platten Michael, Herold-Mende Christel, Unterberg Andreas, Pfister Stefan M, Wick Wolfgang, von Deimling Andreas

Abstract excerpt

With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of neuropathology samples has vastly increased. We therefore developed a customized enrichment/hybrid-capture-based next-generation sequencing (NGS) gene panel comprising the entire coding and selected intronic and promoter regions of 130 genes recurrently altered in brain...

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PMID: 26671409
DOI: 10.1007/s00401-015-1519-8

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