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Article

Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors.

Neuro-oncology - 1 Mar 2016

Nikiforova Marina N, Wald Abigail I, Melan Melissa A, Roy Somak, Zhong Shan, Hamilton Ronald L, Lieberman Frank S, Drappatz Jan, Amankulor Nduka M, Pollack Ian F, Nikiforov Yuri E, Horbinski Craig

Abstract excerpt

BACKGROUND: Identification of genetic changes in CNS tumors is important for the appropriate clinical management of patients. Our objective was to develop a next-generation sequencing (NGS) assay for simultaneously detecting the various types of genetic alterations characteristic for adult and pediatric CNS tumors that can be applied to small brain biopsies. METHODS: We report an amplification-based targeted NGS...

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Identifiers

PMID: 26681766
DOI: 10.1093/neuonc/nov289
PMCID: PMC4767245

Genes

BRAF
ATRX
EGFR
FGFR3
IDH1
PTEN
TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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