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Article

Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas.

Journal of neuropathology and experimental neurology - 1 Jun 2018

Ferguson Sherise D, Zhou Shouhao, Huse Jason T, de Groot John F, Xiu Joanne, Subramaniam Deepa S, Mehta Shwetal, Gatalica Zoran, Swensen Jeffrey, Sanai Nader, Spetzler David, Heimberger Amy B

Abstract excerpt

Gene fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets. Using RNA-sequencing, we interrogated a large cohort of gliomas to assess for the incidence of targetable genetic fusions. Gliomas (n = 390) were profiled using the ArcherDx FusionPlex Assay. Fifty-two gene targets were analyzed and fusions with preserved kinase domains were investigated. Overall, 36 gliomas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29718398
DOI: 10.1093/jnen/nly022
PMCID: PMC5961205

Genes

EGFR
FGFR3
MET
NBR1
VWC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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