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Article

Novel role for mineralocorticoid receptors in control of a neuronal phenotype.

Molecular psychiatry - 1 Jan 2021

McCann Katharine E, Lustberg Daniel J, Shaughnessy Emma K, Carstens Kelly E, Farris Shannon, Alexander Georgia M, Radzicki Daniel, Zhao Meilan, Dudek Serena M

Abstract excerpt

Mineralocorticoid receptors (MRs) in the brain play a role in learning and memory, neuronal differentiation, and regulation of the stress response. Within the hippocampus, the highest expression of MRs is in area CA2. CA2 pyramidal neurons have a distinct molecular makeup resulting in a plasticity-resistant phenotype, distinguishing them from neurons in CA1 and CA3. Thus, we asked whether MRs regulate CA2 neuron...

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Source

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Identifiers

PMID: 31745235
DOI: 10.1038/s41380-019-0598-7
PMCID: PMC7234915

Genes

CA2
CA1
CA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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