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Article

Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2.

Neuron - 19 Jun 2003

Jeon Daejong, Yang Yu-Mi, Jeong Myung-Jin, Philipson Kenneth D, Rhim Hyewhon, Shin Hee-Sup

Abstract excerpt

The plasma membrane Na(+)/Ca(2+) exchanger (NCX) plays a role in regulation of intracellular Ca(2+) concentration via the forward mode (Ca(2+) efflux) or the reverse mode (Ca(2+) influx). To define the physiological function of the exchanger in vivo, we generated mice deficient for NCX2, the major isoform in the brain. Mutant hippocampal neurons exhibited a significantly delayed clearance of elevated Ca(2+)...

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Identifiers

PMID: 12818181
DOI: 10.1016/s0896-6273(03)00334-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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