Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hippocampal phenotypes in kalirin-deficient mice.

Molecular and cellular neurosciences - 1 Jan 2011

Xie Zhong, Cahill Michael E, Radulovic Jelena, Wang Jing, Campbell Susan L, Miller Courtney A, Sweatt J David, Penzes Peter

Abstract excerpt

Regulation of forebrain cellular structure and function by small GTPase pathways is crucial for normal and pathological brain development and function. Kalirin is a brain-specific activator of Rho-like small GTPases implicated in neuropsychiatric disorders. We have recently demonstrated key roles for kalirin in cortical synaptic transmission, dendrite branching, spine density, and working memory. However, little...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Synaptic Transmission
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Hippocampus

Share to Long-Term Potentiation

Share to Mice, Knockout

Share to Neuronal Plasticity

Source

Open in PubMed Open full text

Identifiers

PMID: 20708080
DOI: 10.1016/j.mcn.2010.08.005
PMCID: PMC3576140

Genes

KALRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hippocampal phenotypes in kalirin-deficient mice.PMID 20708080Read ↗

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.Semantic proximity Read ↗

Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome.Semantic proximity Read ↗

Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1.Semantic proximity Read ↗

Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.Semantic proximity Read ↗

Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning.Semantic proximity Read ↗

MARK1 regulates dendritic spine morphogenesis and cognitive functions <i>in vivo</i>Semantic proximity Read ↗

A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development.Semantic proximity Read ↗

Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.Semantic proximity Read ↗

Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus.Semantic proximity Read ↗

KIBRA Regulates AMPA Receptor Expression, Synaptic Plasticity, and Memory in an Age-Dependent MannerSemantic proximity Read ↗

A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory.Semantic proximity Read ↗

Impact of NRSN2 Deficiency on Memory: Disruption of Excitatory Synaptic Plasticity Linked to Reduced Expression of NMDA Receptor Subunits and impaired LTP in the hippocampusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.