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Article

Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.

Scientific reports - 13 Nov 2019

Land Michelle A, Chapman Holly L, Davis-Reyes Brionna D, Felsing Daniel E, Allen John A, Moeller F Gerard, Elferink Lisa A, Cunningham Kathryn A, Anastasio Noelle C

Abstract excerpt

A non-synonymous single nucleotide polymorphism of the human serotonin 5-HT2C receptor (5-HT2CR) gene that converts a cysteine to a serine at amino acid codon 23 (Cys23Ser) appears to impact 5-HT2CR pharmacology at a cellular and systems level. We hypothesized that the Cys23Ser alters 5-HT2CR intracellular signaling via changes in subcellular localization in vitro. Using cell lines stably expressing the wild-type...

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Identifiers

PMID: 31723224
DOI: 10.1038/s41598-019-53124-2
PMCID: PMC6853916

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