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Article

Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.

Pharmacogenetics and genomics - 1 Dec 2008

Krzywkowski Karen, Davies Paul A, Irving Andrew J, Bräuner-Osborne Hans, Jensen Anders A

Abstract excerpt

BACKGROUND: 5-Hydroxytryptamine 3 (5-HT3) receptors mediate the fast excitatory neurotransmission of serotonin. In this study, we have characterized the effects of four naturally occurring, nonsynonymous variants of the human 5-HT3B subunit on expression and signalling properties of heteromeric 5-HT3AB receptors. METHODS AND RESULTS: 5-HT3AB receptor signalling was studied in a fluorescence-based cell membrane...

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PMID: 19008750
DOI: 10.1097/FPC.0b013e328310f950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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