Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jul 2012

Mickey Brian J, Sanford Benjamin J, Love Tiffany M, Shen Pei-Hong, Hodgkinson Colin A, Stohler Christian S, Goldman David, Zubieta Jon-Kar

Abstract excerpt

Mesoaccumbal and nigrostriatal projections are sensitive to stress, and heightened stress sensitivity is thought to confer risk for neuropsychiatric disorders. Serotonin 2C (5-HT(2C)) receptors mediate the inhibitory effects of serotonin on dopaminergic circuitry in experimental animals, and preclinical findings have implicated 5-HT(2C) receptors in motivated behaviors and psychotropic drug mechanisms. In humans,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corpus Striatum
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to Mood Disorders

Share to Radionuclide Imaging

Share to Receptor, Serotonin, 5-HT2C

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 22764241
DOI: 10.1523/JNEUROSCI.1260-12.2012
PMCID: PMC3431013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans.PMID 22764241Read ↗

The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.Semantic proximity Read ↗

Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).Semantic proximity Read ↗

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.Semantic proximity Read ↗

Leptin regulates dopamine responses to sustained stress in humans.Semantic proximity Read ↗

Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.Semantic proximity Read ↗

Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity.Semantic proximity Read ↗

Striatal Dopamine Binding in Anhedonia: A Simultaneous [<sup>11</sup>C]Raclopride Positron Emission Tomography and Functional Magnetic Resonance Imaging InvestigationSemantic proximity Read ↗

Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms.Semantic proximity Read ↗

Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study.Semantic proximity Read ↗

Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress II: Evidence from two samples.Semantic proximity Read ↗

Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.Semantic proximity Read ↗

A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.