Article
Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.
Molecular psychiatry - 1 Sept 2001
Lerer B, Macciardi F, Segman R H, Adolfsson R, Blackwood D, Blairy S, Del Favero J, Dikeos D G, Kaneva R, Lilli R, Massat I, Milanova V, Muir W, Noethen M, Oruc L, Petrova T, Papadimitriou G N, Rietschel M, Serretti A, Souery D, Van Gestel S, Van Broeckhoven C, Mendlewicz J
Abstract excerpt
Substantial evidence supports a role for dysfunction of brain serotonergic (5-HT) systems in the pathogenesis of major affective disorder, both unipolar (recurrent major depression) and bipolar.(1) Modification of serotonergic neurotransmission is pivotally implicated in the mechanism of action of antidepressant drugs(2) and also in the action of mood stabilizing agents, particularly lithium carbonate.(3)...
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