Article
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 2008
Krzywkowski Karen, Davies Paul A, Feinberg-Zadek Paula L, Bräuner-Osborne Hans, Jensen Anders A
Abstract excerpt
The 5-hydroxytryptamine-3 (5-HT3) receptor mediates the fast excitatory neurotransmission of serotonin and is known to mediate the nausea/emesis induced by radio/chemotherapy and anesthetics. A polymorphism encoding the variation Y129S in the 5-HT3B subunit exists in high frequency in the general population and has been shown to be inversely correlated to the incidence of major depression in women. We show that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.