Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).

Genomics - 20 May 1995

Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu D H, Virkkunen M, Weight F, Linnoila M, Goldman D

Abstract excerpt

The function of brain serotonin-2C (5-HT2C) receptors, including behavioral and neurochemical responses to 5-HT2C agonist challenge, has been suggested to be abnormal in individuals with neuropsychiatric disorders. Thus, it is important to identify polymorphisms and functional variants within this gene. Using SSCP analysis, we identified a Cys23-Ser23 substitution (designated 5-HT2Ccys and 5-HT2Cser) in the first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Gene Frequency

Share to Genetic Linkage

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Point Mutation

Source

Identifiers

PMID: 7557992
DOI: 10.1006/geno.1995.1042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).PMID 7557992Read ↗

Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms.Semantic proximity Read ↗

Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.Semantic proximity Read ↗

Identification of a new polymorphism in the 3'-untranslated region of the human serotonin receptor 2C (5-HT2C) gene.Semantic proximity Read ↗

Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.Semantic proximity Read ↗

Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability.Semantic proximity Read ↗

Genetic variation in human 5-HT receptors: potential pathogenetic and pharmacological role.Semantic proximity Read ↗

Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder.Semantic proximity Read ↗

Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans.Semantic proximity Read ↗

Evaluation of a Cys23Ser mutation within the human 5-HT2C receptor gene: no evidence for an association of the mutant allele with obesity or underweight in children, adolescents and young adults.Semantic proximity Read ↗

Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study.Semantic proximity Read ↗

The N-terminal region of the human 5-HT₂C receptor has as a cleavable signal peptide.Semantic proximity Read ↗

The effect of cancer-associated mutations on ligand binding and receptor function - A case for the 5-HT2C receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.