Article
Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).
Genomics - 20 May 1995
Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu D H, Virkkunen M, Weight F, Linnoila M, Goldman D
Abstract excerpt
The function of brain serotonin-2C (5-HT2C) receptors, including behavioral and neurochemical responses to 5-HT2C agonist challenge, has been suggested to be abnormal in individuals with neuropsychiatric disorders. Thus, it is important to identify polymorphisms and functional variants within thi...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Cysteine
- Electrophysiology
- Gene Expression
- Gene Frequency
- Genetic Linkage
- Genetic Variation
- Humans
- Molecular Sequence Data
- Oocytes
- Point Mutation
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
- Serine
- Serotonin
- Xenopus laevis