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Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma

11 Nov 2019

Abstract excerpt

Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Myeloma (SMM) consistently precede symptomatic Multiple Myeloma (MM) requiring systemic therapy [ 1 ]. Several factors have been identified to predict higher risk of progression in asymptomatic patients [ 2 ]. High-risk chromosomal aberrations (CA) are associated with an increased risk of progression into symptomatic myeloma [ 2 , 3 , 4 ]....

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PMID: 31712777
DOI: 10.1038/s41375-019-0634-2

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