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Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na+,K+-ATPase α2-Isoform.

Cells - 7 Apr 2023

Rajanathan Rajkumar, Riera Clàudia Vilaseca I, Pedersen Tina Myhre, Staehr Christian, Bouzinova Elena V, Nyengaard Jens Randel, Thomsen Morten B, Bøtker Hans Erik, Matchkov Vladimir V

Abstract excerpt

Two α-isoforms of the Na+,K+-ATPase (α1 and α2) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility. Mice heterozygous for the familial hemiplegic migraine type 2 (FHM2) associated mutation in the α2-isoform (G301R; α2+/G301R mice) have decreased expression of cardiac α2-isoform but elevated expression of the α1-isoform. We aimed to...

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Identifiers

PMID: 37190017
DOI: 10.3390/cells12081108
PMCID: PMC10136638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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