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Article

Sex-specific mechanisms of cerebral microvascular BK <sub>Ca</sub> dysfunction in a mouse model of Alzheimer’s disease

2023-06-08

Abstract excerpt

<h4>Background</h4> Cerebral microvascular dysfunction and nitro-oxidative stress are present in patients with Alzheimer’s disease (AD) and may contribute to disease progression and severity. Large conductance Ca 2+ -activated K + channels (BK Ca ) play an essential role in vasodilatory responses and maintenance of myogenic tone in resistance arteries. BK Ca impairment can lead to microvascular dysfunction an...

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Literature Corpus work
618cfeba-9a9e-58fa-97d4-9d200443cae9
DOI
10.1101/2023.06.06.543962
Open publication

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Sex-specific mechanisms of cerebral microvascular BK <sub>Ca</sub> dysfunction in a mouse model of Alzheimer’s diseaseDOI 10.1101/2023.06.06.543962
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