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Article

Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for FHM2.

Scientific reports - 16 Nov 2018

Kros Lieke, Lykke-Hartmann Karin, Khodakhah Kamran

Abstract excerpt

Migraine is a highly prevalent, debilitating, episodic headache disorder affecting roughly 15% of the population. Familial hemiplegic migraine type 2 (FHM2) is a rare subtype of migraine caused by mutations in the ATP1A2 gene, encoding the α2 isoform of the Na+/K+-ATPase, predominantly expressed in astrocytes. Differential comorbidities such as epilepsy and psychiatric disorders manifest in patients. Using a...

Read the complete abstract on PubMed

Topics

Age Factors
Animals
Cortical Spreading Depression
Disease Models, Animal
Epilepsy
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Isoenzymes

Male

Mice

Migraine Disorders

Migraine with Aura

Mutation

Sodium-Potassium-Exchanging ATPase

Source

Open in PubMed Open full text

Identifiers

PMID: 30446731
DOI: 10.1038/s41598-018-35285-8
PMCID: PMC6240030

Genes

ATP1A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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