Article
Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.
Journal of the American Heart Association - 5 Apr 2022
Staehr Christian, Rohde Palle Duun, Krarup Nikolaj Thure, Ringgaard Steffen, Laustsen Christoffer, Johnsen Jacob, Nielsen Rikke, Beck Hans Christian, Morth Jens Preben, Lykke-Hartmann Karin, Jespersen Nichlas Riise, Abramochkin Denis, Nyegaard Mette, Bøtker Hans Erik, Aalkjaer Christian, Matchkov Vladimir
Abstract excerpt
Background Mutations in ATP1A2 gene encoding the Na,K-ATPase α2 isoform are associated with familial hemiplegic migraine type 2. Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function, but its role for heart disease remains unknown. We hypothesized that ATP1A2 is a susceptibility gene for heart disease and aimed to assess the underlying disease mechanism....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.