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Article

Mechanisms of the factor V Leiden paradox.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2008

van Stralen K J, Doggen C J M, Bezemer I D, Pomp E R, Lisman T, Rosendaal F R

Abstract excerpt

OBJECTIVE: Carriers of the factor V Leiden mutation (FVL-carriers) have a substantially increased risk of deep venous thrombosis (DVT), whereas the risk of pulmonary embolism (PE) is only mildly increased compared with noncarriers. So far few studies have investigated possible mechanisms for this so-called FVL paradox. METHODS AND RESULTS: Consecutive patients with a first DVT or PE were included in a large...

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Identifiers

PMID: 18617648
DOI: 10.1161/ATVBAHA.108.169524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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