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Article

HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage

7 Nov 2019

Abstract excerpt

The histone deacetylases (HDACs)-dependent mechanisms regulating gene transcription of the Na + /Ca + exchanger isoform 3 ( ncx3) after stroke are still unknown. Overexpression or knocking-down of HDAC4/HDAC5 down-regulates or increases, respectively, NCX3 mRNA and protein. Likewise, MC1568 (class IIa HDACs inhibitor), but not MS-275 (class I HDACs inhibitor) increased NCX3 promoter activity, gene and protein...

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Share to Cholinesterase and Neurodegenerative Diseases
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PMID: 31696766
DOI: 10.1177/0271678x19884742

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