Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.

doi:10.1124/mol.112.080986

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Article

Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.

Molecular pharmacology - 1 Jan 2013

Molinaro Pasquale, Cantile Maria, Cuomo Ornella, Secondo Agnese, Pannaccione Anna, Ambrosino Paolo, Pignataro Giuseppe, Fiorino Ferdinando, Severino Beatrice, Gatta Elena, Sisalli Maria José, Milanese Marco, Scorziello Antonella, Bonanno Giambattista, Robello Mauro, Santagada Vincenzo, Caliendo Giuseppe, Di Renzo Gianfranco, Annunziato Lucio

Abstract excerpt

Previous studies have demonstrated that the knockdown or knockout of the three Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, worsens ischemic brain damage. This suggests that the activation of these antiporters exerts a neuroprotective action against stroke damage. However, drugs able to increase the activity of NCXs are not yet available. We have here succeeded in synthesizing a new compound,...

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PMID: 23066092
DOI: 10.1124/mol.112.080986

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