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Intravenous antagomiR-494 lessens brain-infiltrating neutrophils by increasing HDAC2-mediated repression of multiple MMPs in experimental stroke

2019-11-19

Abstract excerpt

<h4>Background: </h4> Neutrophil infiltration and phenotypic transformation are believed to contribute to neuronal damage and clinical outcome in ischemic stroke. Emerging evidence suggests that HDAC2 is an epigenetic regulator of inflammatory cells. Here, we investigated whether miR-494 affects HDAC2-mediated neutrophil infiltration and phenotypic shift. <h4>Methods:</h4> The miR-494 levels in neutrophils from AI...

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Literature Corpus work
55b61750-344b-5fc3-9a61-fd79e213a39f
DOI
10.21203/rs.2.17389/v1
Open publication

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