Epigenetic Reactivation of CNS Endothelial Developmental Programs Triggers Adult Brain Angiogenesis, Promotes Post-Stroke Revascularization and Neuronal Regeneration

Abstract excerpt

Therapeutic angiogenesis is essential for regenerating brain tissue damaged by stroke, yet it remains an unmet clinical challenge. During brain development, pro-angiogenic genes drive the formation of vascular networks, with their expression tightly regulated in later stages. We found that in adult CNS endothelial cells (ECs), angiogenesis-related genes are epigenetically silenced through histone deacetylase 2 (HD...

Topics

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• Hindlimb
• Histone Deacetylase Inhibitors Research
• Histone Deacetylases
• Human Umbilical Vein Endothelial Cells
• Intracerebral and Subarachnoid Hemorrhage Research
• Moyamoya disease diagnosis and treatment
• Vascular Anomalies and Treatments
• Vascular Malformations Diagnosis and Treatment

Identifiers and source

Literature Corpus work

3a419f7d-6eec-5e7a-ab9b-58c3cb33a134

DOI

10.1101/2025.08.15.670554