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Article

Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux.

PloS one - 1 Jan 2013

Nunes Maria João, Moutinho Miguel, Gama Maria João, Rodrigues Cecília M P, Rodrigues Elsa

Abstract excerpt

Cholesterol is an essential component of the central nervous system and increasing evidence suggests an association between brain cholesterol metabolism dysfunction and the onset of neurodegenerative disorders. Interestingly, histone deacetylase inhibitors (HDACi) such as trichostatin A (TSA) are...

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Identifiers

PMID: 23326422
DOI: 10.1371/journal.pone.0053394
PMCID: PMC3542332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23326422-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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