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Potential therapeutic targets for ischemic stroke in pre-clinical studies: Epigenetic-modifying enzymes DNMT/TET and HAT/HDAC

28 Apr 2025

Abstract excerpt

Ischemic stroke (IS) remains a leading cause of mortality and disability worldwide, driven by genetic predispositions and environmental interactions, with epigenetics playing a pivotal role in mediating these processes. Specific modifying enzymes that regulate epigenetic changes have emerged as promising targets for IS treatment. DNA methyltransferases (DNMTs), ten-eleven translocation (TET) dioxygenases, histone...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

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PMID: 40356977
DOI: 10.3389/fphar.2025.1571276

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